Nucleic acid free ghost preparations

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

Reexamination Certificate

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Details

C424S093200, C424S234100, C424S093100, C514S002600, C435S069100, C435S320100, C435S199000, C536S023100, C536S023200, C536S023700

Reexamination Certificate

active

07399476

ABSTRACT:
The invention relates to preparations of bacterial ghosts which are substantially free of living bacterial cells and/or nucleic acids and their use in pharmaceutical preparations.

REFERENCES:
patent: 6177083 (2001-01-01), Lubitz
patent: WO-95/10614 (1995-04-01), None
Haidinger et al., “Green Fluorescent protein (GFP)-dependent separation of bacterial . . . ” Cytometry, vol. 44, No. 2, Jun. 1, 2001, pp. 106-112.
Szostak et al., “Bacterial ghosts as multifunctional vaccine particles”, Behring Institute, No. 98, 1997, pp. 191-196.
Szostak et al., “Bacterial ghosts: non-living candidate vaccine”, Journal of Biotechnology, Elsevier Science Publishers, vol. 44, No. 1, Jan. 26, 1996, pp. 161-170.
Lubitz et al., “Extended recombinant bacterial ghost system”, Journal of Biotechnology, Elsevier Science Publishers, vol. 73, No. 2-3, Aug. 20, 1999, pp. 261-273.
Eko et al., “New strategies for combination vaccines based on the extended recombinant bacterial ghost system”, Vaccine, Butterworth Scientific., vol. 17, No. 13-14, Jan. 1999, pp. 1643-1649.
Mader et al., “Endotoxicity does not limit the use of bacterial ghosts as candidate vaccines”, Vaccine, Butterworth Scientific, vol. 15, No. 2, Feb. 1, 1997, pp. 195-202.
Huter et al., “Bacterial ghosts as drug carrier and targeting vehicles”, Journal of Controlled Release, vol. 61, No. 1-2. Aug. 27, 1999, pp. 51-63.

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