Nucleic acid fragments derived from the HIV-1 virus genome, corr

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

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4241871, 4241881, 4242071, 435 71, 435 792, 435 691, 435 693, 530300, 530326, 530329, A61K 3921, C07K 402

Patent

active

059194626

ABSTRACT:
This invention provides specific amino acid sequences encoded by nucleic acid fragments derived from the genome of the human immunodeficiency virus type 1 (HIV-1) and to peptides containing such amino acid sequences. The invention further provides immunogenic compositions containing the disclosed amino acid sequences and their associated peptides. The amino acids and peptides of this invention are useful as reagents for the screening, detection and evaluation for the risk of maternofoetal transmission of HIV-1.

REFERENCES:
L. Q. Zhang et al., Journal of Virology, vol. 67, No. 6, pp. 3345-3356 (1993): Selection for Specific Sequences in the External Envelope Protein of Human Immunodeficiency Virus Type 1 upon Primary Injection.
M. Cornelissen et al., Journal of Virology, vol. 69, No. 3, pp. 1810-1818 (1995): Syncytium-Inducing (SI) Phenotype Suppression at Seroconversion after Intramuscular Inoculation of a Non-Syncytium-Inducing/SI Phenotypically Mixed Human Immunodeficiency Virus Population.

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