Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge
Patent
1990-08-06
1992-05-05
Niebling, John
Chemistry: electrical and wave energy
Processes and products
Electrostatic field or electrical discharge
204299R, G01N 2726, B01D 5702
Patent
active
051104245
ABSTRACT:
A method of fractionating nucleic acid fragments is disclosed. The method is based on counter migration of the fragments in an upstream direction through a polymer solution which is moving by electroosmotic flow in a downstream direction. Fractionation of selected-size nucleic acid fragments can be enhanced by reducing the difference between the electroosmotic flow rate and the migration rates of the selected-size fragments.
REFERENCES:
Jan Sudor et al., "Step change of counterion-a new option in capillary zone electrophoresis" Electrophoresis 10 (1989) 802-805.
Cohen, A. S. et al., Anal. Chem. 59:1021 (1987).
Cohen, A. S. et al., J. Chromatography 458:323 (1988).
Compton, S. W. et al., Biotechniques 6(5):432 (1988).
Lauer, H. H. et al., Anal. Chem. 58:166 (1986).
Kasper, T. J. et al., J. Chromatography 458:303 (1988).
McCormick, R. M. et al., Anal. Chem. 60(21):2322 (1988).
Herren, B. J. et al., J. Colloid and Interface Sci. 115(1):46 (1987).
Bio-Rad Advertisement Bulletin #1456, pp. 1-4 (1989).
Bio-Rad Advertisement Bulletin #1479, pp. 1-2 (1989).
Zhu, M. et al., J. Chromatog. 408:311 (1989).
Applied Biosystems Inc.
Dehlinger Peter J.
Fabian Gary R.
Niebling John
Smith Joseph
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