Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-03-22
2011-03-22
Bowman, Amy (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C514S04400A, C424S093100
Reexamination Certificate
active
07910721
ABSTRACT:
The present invention provides a method for controlling cleavage of a target RNA by deoxyribozyme.The present inventors designed a nucleic acid-enzyme complex using GGA 12-mer (Reference 3), which was found in the laboratory of the inventors to have greatly changeable structure in the presence or absence of monovalent metal ion as well as previously known nucleic acid-enzyme. The present invention is a deoxyribozyme complex comprising deoxyribozyme having a nucleotide sequence of target RNA, a substrate binding domain and a catalytic domain of RNA cleavage reaction, and a sequence (5′GGAGGAGGAGGA3′(SEQ ID NO: 21)), wherein the sequence is inserted to the catalytic domain of RNA cleavage reaction.
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Bowman Amy
Jenkins Wilson Taylor & Hunt, P.A.
National University Corporation Yokohama National University
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