Nucleic acid encoding α chain of human IL-11 receptor

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Details

C435S069100, C435S252300, C435S320100, C435S471000

Reexamination Certificate

active

07002000

ABSTRACT:
The present invention relates generally to novel haemopoietin receptors, or components or parts thereof and to a method for cloning genetic sequences encoding same. More particularly, the subject invention is directed to recombinant or synthetic haemopoietin receptors or components or parts thereof. The receptor molecules or components or parts thereof and their genetic sequences of the present invention are useful in the development of a wide range of agonists, antagonists and therapeutics and diagnostic reagents based on ligand interaction with its receptor.

REFERENCES:
patent: WO 91/18982 (1991-12-01), None
patent: WO 93/18037 (1993-09-01), None
patent: WO 96/19574 (1996-06-01), None
Gorman DM, et al. 1993. J. Biol. Chem. vol. 267: 15842-15848, Chomosomal localization and organization of the murine genes encoding the beat subunits (AlC2A and AlC2B) of the interleukin 3, granulocyte/macrophage colony stimulating factor, and intereluikn 5.
Born et al. 2000. J Biol Chem. vol. 275, pp. 29946-29954. Identification and characterization of two novel emembers of a novel class of the interleukin-1 receptor (IL-1R) family.
Reiger et al. (1996) Glossary of Genetics and Cytogenetics, 4th edition, Springer-Verlag, pp. 16-19.
Gorman, et al. (Jul. 1990) “Cloning and Expression of a Gene Encoding an Interleukin 3 Receptor-Like Protein: Identification of Another Member of the Cytokine receptor Gene Family”Proc. Natl. Acad. Sci. USA 87:5459-5463.
Hilton, et al. (1994) “Cloning of a Murine IL-11 Receptor α-Chain; Requirement for gp130 for High Affinity Binding and Signal Transduction”The EMBO Journal 13(20):4765-4775.
Itoh, et al. (Jan. 19, 1990) “Cloning of an Interleukin-3 Receptor Gene: A Member of a Distinct Receptor Gene Family”Science 247:324-327.
Tashiro, et al. (Jul. 30, 1993) “Signal Sequence Trap: A Cloning Strategy for Secreted Proteins and Type I Mambrane Proteins”Science 261:600-601.

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