Nucleic acid encoding vertebrate cdc37

Details Nucleic acid encoding vertebrate cdc37 Nucleic acid encoding vertebrate cdc37

1996-07-05

2000-05-23

Ketter, James

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, C07H 2104

Patent

active

060667230

ABSTRACT:
Disclosed are substantially pure nucleic acid sequences encoding vertebrate cdc37. The protein encoded by this nucleic acid is characterized by the ability to bind specifically to mammalian proteins selected from the group consisting of cdk4, cyclin D, cdk2, Rb, hsp90, hsp60, hsp70, Raf-1, MEK-1, SAPK, MAPK, ERK1, P13-K and the src family of tyrosine kinases. In addition, the protein is further characterized by the ability to bind glycosaminoglycan. Also disclosed are diagnostic and therapeutic applications based on the isolation of the nucleic acid sequences.

REFERENCES:
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Qin Yu et al., Developmental Dynamics 193: 145-151 (1992).
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Cutforth and Rubin, Cell 77: 1027-1036 (1994).
Grammatikakis et al., J. Biol. Chem. 270: 16198-16205 (1995).
Stepanova et al., Genes and Devel. 10: 1491-1502 (1996).

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