Nucleic acid encoding ubiquitin-specific proteases

Details Nucleic acid encoding ubiquitin-specific proteases Nucleic acid encoding ubiquitin-specific proteases

1991-11-08

1993-05-18

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

536 232, 536 234, 4353201, 4352402, 4352523, 435 6, C12Q 168, C07H 2104, C12N 1557, C12N 1566, C12N 1570

Patent

active

052120589

ABSTRACT:
The disclosure relates to a generic class of ubiquitin-specific proteases which specifically cleave at the C-terminus of the ubiquitin moiety in a ubiquitin fusion protein irrespective of the size of the ubiquitin fusion protein. More specifically, the disclosure relates to ubiquitin-specific proteases of this class which have been isolated from a cell. The disclosure also relates to isolated DNA sequences encoding the proteases of this class.

REFERENCES:
patent: 5132213 (1992-07-01), Bachmair et al.
Ohmen et al. N.A.R. 16(22): 10783-10802, 1988.
Ohmen et al. Mol. Cell Biol. 10(6):3027-3035, 1990.
K. Nagai and H. C. Thogersen, Nature 309:810-812 (1984).
Hershko et al., Proc. Natl. Acad. Sci. USA 81:7021-7025 (1984).
Tsunasawa et al., J. Biol. Chem. 260:5382-5391 (1985).
Boissel et al., Proc. Natl. Acad. Sci. USA 82:8448-8452 (1985).
Thornton et al., J. Mol. Biol. 167:443-460 (1983).
Ferber et al., J. Biol. Chem. 261:3128-3134 (1986).
Bachmair et al., Science 234:179-186 (1986).
Ferber et al., Nature 326:808-811 (1988).
Reiss et al., J. Biol. Chem. 263:2693-2698 (1988).
Townsend et al., J. Exp. Med. 168:1211-1224 (1988).
Bachmair and Varshavsky, Cell 56:1019-1032 (1989).
Chau et al., Science 243:1576-1583 (1989).
Gonda et al., J. Biol. Chem. 264: 16700-16712 (1989).
Miller et al., Biotechnology 1:698-704 (1989).
International Search Report.
Sassenfeld, Trends in Biotechnol 8:88-93 (1990).
Wilkinson et al., Science 246:670-673 (1989).
Tobias and Varshavsky, J. Biol. Chem. 266:12021-12028 (1991).

Affiliated with

Also associated with

Rating

Nucleic acid encoding ubiquitin-specific proteases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid encoding ubiquitin-specific proteases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid encoding ubiquitin-specific proteases will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-803646