Nucleic acid encoding transcription factor p300 and uses of p300

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

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4352523, 4353201, 435366, 536 235, 536 2431, C07H 2104

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056587848

ABSTRACT:
The invention features an isolated nucleic acid hybridizable with the complement of the coding strand nucleic acid sequence presented in SEQ ID NO:1, and encoding a protein that is necessary for adenovirus transformation of a mammalian cell. The encoded protein, p300, cooperates with adenovirus E1A (Early-region 1A) proteins to establish the transformed state.

REFERENCES:
patent: 5262321 (1993-11-01), Livingston et al.
Chrivia et al., "Phosphorylated CREB binds specifically to the nuclear protein CBP," Nature 365:855-859 (1993).
Hans van Dam et al. "Differential Effects of the Adenovirus E1A Oncogene . . . ", Molecular and Cellular Biology 10:5857-5864, Nov. 1990.
Velcich et al, "Adenovirus E1a Proteins Repress Transcription . . . ", Cell 40:705-716, Mar. 1985.
Yee et al., "Detection of Cellular Proteins Associated with Human . . . ", Virology 147:142-153, 1985.
Braun et al., "Inhibition of Muscle Differentiation by the Edenovirus E1a Protein . . . ", Genes & Development 6:888-902, 1992.
Wang et al., "E1A Induces Phosphorylation of the Retinoblastoma Protein . . . ", Molecular and Cellular Biology 11:4253-4265, Aug. 1991.
Yaciuk et al., "Analysis with Specific Polyclonal Antiserum Indicates . . . ", Molecular and Cellular Biology 11:5389-5397, Nov. 1991.
Stein et al., "Analysis of E1A-Mediated Growth Regulation Functions: . . . ", Journal of Virology 64:4421-4427, Sep. 1990.
Whyte et al., "Cellular Targets for Transformation by the Adenovirus E1A Proteins", Cell 56:67-75, Jan. 1989.
Caruso et al., "Regulation of MyoD Gene Transcription and Protein . . . ", Istituto Biologia Cellulare, CNR, Rome, Italy, Aug. 1992.
Moran et al., "Interactions between Cell Growth-Regulating Domains . . . ", Molecular and Cellular Biology 8:1756-1764, Apr. 1988.
Fisher et al., "Mutational Analysis of the Adenovirus E1a Gene: . . . ", The Embo Journal 6:2053-2060, 1987.
Zerler et al., "Different Functional Domains of the Adenovirus E1A Gene Are Involved in Regulation . . . ", Molecular and Cellular Biology 7:821-829, Feb. 1987.
Harlow et al., "Association of Adenovirus Early-Region 1A Proteins with Cellular Polypeptides", Molecular and Cellular Biology 6:1579-1589, May 1986.
Rigby, Peter W.J., "Three in One and One in Three: It all Depends on TBP", Cell 72:7-10, Jan. 15, 1993.
Abraham et al., "p300 and p300-associated Proteins, Are Components . . . ", Oncogene 8:1639-1647, 1993.
Borrelli et al., "Adenovirus-2 E1A Products Repress Enhancer-Induced . . . ", Nature 312:608-612, Dec. 1984.
Lloyd et al., "Transformation Suppressor Activity of a Jun Transscription Factor . . . ", Nature 352:635-638, Aug. 1991.
Rikitake et al., Mol. Cell. Biol. 12(6), 2826-2836 (1992).
Howe et al., PNAS 87, 5883-5887 (1990).
Adams et al., Nature Genetics 4, 256-267 (1993).
Eckner et al., Genes Develop. 8(8), 869-884 (1994).

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