Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-10-07
1997-07-01
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 701, 435348, 4352523, 4353201, 435325, 435365, 4353651, 935 22, 935 69, 935 70, 935 72, 536 231, 536 235, 536 243, 536 2431, C12N 1512, C07K 14705
Patent
active
056437552
ABSTRACT:
The present invention provides for TIE-2 ligand substantially free of other proteins. The invention also provides for an isolated nucleic acid molecule encoding TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds TIE-2 ligand. The invention also provides an antibody which specifically binds TIE-2 ligand. The invention further provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization and a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor.
REFERENCES:
Derynck et al. 1990, Biochemistry, vol. 29, pp.10225-10233.
Weissenbach et al. 1980, Proc. Natl. Acad, Sci, vol. 77, No. 12, pp. 7152-7156.
Aldrich Thomas
Davis Samuel
Yancopoulos George D.
Cobert Robert J.
Kempler Gail M.
Mertz Prema
Regeneron Pharmaceuticals Inc.
Ulm John
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