Nucleic acid encoding the D.sub.2 /Ml chimeric receptor

Details Nucleic acid encoding the D.sub.2 /Ml chimeric receptor Nucleic acid encoding the D.sub.2 /Ml chimeric receptor

1991-01-22

1993-11-23

Hill, Jr., Robert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 235, 530350, 5303871, 4352402, 4353201, 435 691, 435 694, C12P 2100, C12N 500, C07K 300, C07H 1700

Patent

active

052645657

ABSTRACT:
Chimeric G-protein linked receptors are constructed which retain ligand binding specificity yet gain the ability to elevate intracellular free calcium as a result of agonist binding. This easily assayed function is provided by the insertion of or replacement with sequences substantially homologous to the i3 loop of a second G-protein-linked receptor. Such receptors are employed, for example, in methods of screening for compounds capable of acting as agonists or antagonists of G-protein-linked receptors.

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