Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-11-06
1998-05-05
Teng, Sally
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2431, 435 691, C12N 1509, C07H 2100
Patent
active
057476608
ABSTRACT:
A new protein is described, prostaglandin F.sub.2.alpha. receptor regulatory protein (FPRP), which is able to inhibit the binding of prostaglandin F.sub.2.alpha. (PGF.sub.2.alpha.) to its receptor (FP). Included are pharmaceutical compositions of FPRP and FPRP variants for treatment of PGF.sub.2.alpha. -mediated disorders, and assays for detecting FP in a biological sample.
REFERENCES:
patent: 5211937 (1993-05-01), Brandley et al.
Orlicky, D., et al., Binding and Second Messengers of Prostaglandins F2.alpha. and E.sub.1 in Primary Cultures of Rabbit Endometrial Cells, Journal of Cellular Physiology, 127:61-72, (1986).
Orlicky, D., et al., Identification and Purification of a Bovine Corpora Binding Properties, Prostaglandin Leukotrienes and Essential Fatty Acids, 41:51-61, (1990). Binding Reexamine, Prostaglandins Leukotrienes and Essential Fatty Acids, 40:181-189, (1990).
Orlicky, D., et al., Immunohistochemical Localization of PGF.sub.2.alpha. Receptor in the Rat Ovary, Prostaglandins Leukotrienes and Essential Fatty Acids, 46:223-229, (1992).
Orlicky, D., et al., Immunohistochemical Localization of PGF.sub.2.alpha. Receptor in the Mouse Testis, Prostaglandins Leukotrienes and Essential Fatty Acids, 47:247-252, (1992).
Orlicky, D., et al., Immunohistochemical Localization of PGF.sub.2.alpha. Receptor in the Rat Oviduct, Prostaglandins Leukotrienes and Essential Fatty Acids, 48:185-192, (1993).
Coleman, R., et al., Pharmacological Reviews, vol. 46, No. 2, 205-227.
Sugimoto, Y., et al., Cloning and Expression of a cDNA for Mouse Prostaglandin F Receptor, The Journal of Biological Chemistry, vol. 269, No. 2, 1356-1360.
Wieptz, G.J., et al., Receptors for Prostaglandins F.sub.2.alpha. and E.sub.2 in Ovine Corpora Lutea during Maternal Recognition of Pregnancy, Biology of Reproduction, 47:984-991, (1992).
Bozicevic Karl
Teng Sally
The University of Colorado
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