Nucleic acid encoding novel human G-protein coupled receptor

Details Nucleic acid encoding novel human G-protein coupled receptor Nucleic acid encoding novel human G-protein coupled receptor

1996-08-14

1998-06-09

Teng, Sally P.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 235, 435325, 4352523, 43525411, 4353201, C12N 1512, C07K 14705

Patent

active

057632189

ABSTRACT:
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

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