Nucleic acid encoding modified human tnf.alpha. (tumor necrosis

Details Nucleic acid encoding modified human tnf.alpha. (tumor necrosis Nucleic acid encoding modified human tnf.alpha. (tumor necrosis

1995-06-06

1999-01-26

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 691, 435 693, 4353201, 536 234, 536 235, C12N 510, C12N 1512, C12N 1562

Patent

active

058637869

ABSTRACT:
A DNA molecule is provided which encodes a polypeptide which is capable of binding human TNF.alpha. and which has the first three cysteine-rich subdomains, but not the fourth cysteine-rich subdomain, of the extracellular binding domain of a receptor selected from the 55 kD and 75 kD receptors for human TNF.alpha.. The ability of the polypeptide to bind to TNF.alpha. means that it can be used for treating diseases mediated by TNF.alpha. activity, such as rheumatoid arthritis.

REFERENCES:
Schall et al., Cell (1990) 61:361-370.
Loetscher et al., Cell (1990) 61:351-359.
Gray et al., Proc. Natl. Acad. Sci. USA (1990) 87:7380-7384.
Yan et al., J. Biol. Chem. (1991) 266(18):12098-12104.

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