Nucleic acid encoding mesothelin, a differentiation antigen pres

Details Nucleic acid encoding mesothelin, a differentiation antigen pres Nucleic acid encoding mesothelin, a differentiation antigen pres

1998-12-17

2000-11-28

Eyler, Yvonne

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

536 235, 536 231, 530350, 435 691, 435 693, C12N 516, C12N 1579, C12N 1509, C07H 2102, C07H 2104

Patent

active

061534307

ABSTRACT:
This invention relates to the discovery of a differentiation antigen termed mesothelin which is associated with mesotheliomas and ovarian cancers. Mesothelin is about 69 kD in its full-length form. The invention includes uses for the amino acid and nucleic acid sequences for mesothelin, recombinant cells expressing it, methods for targeting and/or inhibiting the growth of cells bearing mesothelin, methods for detecting the antigen and its expression level as an indication of the presence of tumor cells, and kits for such detection.

REFERENCES:
patent: 5320956 (1994-06-01), Willingham et al.
patent: 5498698 (1996-03-01), Yamaguchi et al.
patent: 5608039 (1997-03-01), Pastan et al.
patent: 5723318 (1998-03-01), Yamaguchi et al.
Yamaguchi, Nozomi et al., "A Novel Cytokine Exhibiting Megakaryocyte Potentiating Activity From a Human Pancreatic Tumor Cell Line HPC-Y5", J. Biol. Chem. vol. 269, No. 2: 805-808 (1994).
Chang, K. Et al., Intl. J. Cancer., 50:373 (1992).
Chang, K. et al., Cancer Res., 52:181 (1992).
Chang, K. et al., Intl. J. Cancer, 57:90 (1994).
Chang, K. et al., Intl. J. Cancer, 51:548 (1992).
Tetsu Kojima et al., Journal of Biological Chemistry, 270:21984 (1995).
Chang, K. et al., Proceedings of the National Academy of Sciences of the United States of America, 93:136 (1996).
Bast, R. et al., N. Eng. J. Med., 309:883-887 (1983).
Campbell, I.G. et al., Cancer Res., 51:5329-5338 (1991).
Chang, K. et al., Am. J. Surg. Pathol., 16:259-268 (1992).
Akiyama, Shin-Ichi et al., J. of Cell. Phys., 120:271-279 (1984).
Database Geneseq. Accession No. R53991. Hattori, K. et al. Megakaryocyte potentiator. (1994).

Affiliated with

Also associated with

Rating

Nucleic acid encoding mesothelin, a differentiation antigen pres does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid encoding mesothelin, a differentiation antigen pres, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid encoding mesothelin, a differentiation antigen pres will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1724117