Nucleic acid encoding mammalian Ubr1

Details Nucleic acid encoding mammalian Ubr1 Nucleic acid encoding mammalian Ubr1

1999-01-11

2000-12-12

Brusca, John S.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4352523, 435 6, 536 231, 536 243, C12N 500

Patent

active

061597325

ABSTRACT:
Disclosed here is a nucleic acid sequence encoding a recognition component of the N-end rule pathway. This nucleic acid sequence is characterized by the ability to specifically hybridize to the nucleic acid sequence of SEQ ID NO 1 under stringent hybridization conditions. Such conditions are defined below. Also disclosed is a nucleic acid sequence encoding a recognition component of the N-end rule pathway which is characterized by the ability to specifically hybridize to the nucleic acid sequence of SEQ ID NO 2 under stringent hybridization conditions. Also disclosed are DNA expression vectors containing nucleic acid sequences of the type described above, as well as cells transformed with such expression vectors. Further disclosed are applications for the compositions described above.

REFERENCES:
Wallace Robert W, "Does antisense make sense?", DDT, 1/99, vol. 1, pp. 4-5.
Agrawal, S., "Antisense oligonucleotides: twoards clinical trials", Trends in Biotechnology, 10/96, vol. 14, No. 10, pp. 376-87.

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