Nucleic acid encoding human signal transducer and activator of t

Details Nucleic acid encoding human signal transducer and activator of t Nucleic acid encoding human signal transducer and activator of t

1997-04-23

1998-05-26

Ulm, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530350, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530331, C12N 1512

Patent

active

057567000

ABSTRACT:
The invention provides methods and compositions relating to interleukin 12 signal transducers, particularly an isolated human signal transducer and activator of transcription 4 (hStat 4), or a fragment thereof having an hStat 4-specific binding affinity, nucleic acids encoding hStat 4, which nucleic acids may be part of hStat 4-expression vectors and may be incorporated into a recombinant cell, agents which selectively bind hStat 4 or hStat 4 intracellular binding targets, or disrupt the binding of hStat 4 to such intracellular targets, methods of making such agents and hStat 4-specific binding targets in the form of cell surface proteins and nucleic acids. An hStat 4 drug screening assay involves forming mixtures of an hStat 4, an intracellular hStat 4 binding target, and a prospective agent at different concentrations. The mixtures are incubated to permit the binding of the intracellular hStat 4 binding target to the hStat 4 and the mixtures are then analyzed for the presence of such binding. A difference in such binding between the first and second mixtures indicates that the agent is capable of modulating the binding of hStat 4 to an intracellular hStat 4 binding target.

REFERENCES:
Patent Abstracts of Japan C-482, p.154, JP 62-223159 (A).
Patent Abstracts of Japan C-685, p. 71, JP 1-287022 (A).
Patent Abstracts of Japan C-561, p. 141, JP 63-230633 (A).

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