Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1999-11-30
2000-10-31
Jones, W. Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 221, 536 241, 536 243, 536 2433, 435 6, 435 691, 4352402, 435810, 935 77, 935 78, C07H 2102
Patent
active
061404853
ABSTRACT:
Nucleic acids encoding each of three subunits, .alpha.1B, .alpha.2.delta., and .beta.3, of a calcium channel, are disclosed. Also disclosed are vectors containing the nucleic acids encoding the subunits; host cells containing the nucleic acids encoding the subunits; methods of isolating nucleic acids encoding related calcium channel subunits; the subunit proteins; fusion proteins comprising the subunit proteins; antibodies to the subunit proteins; assays to identify agents that modulate calcium channel activity, and agents identified thereby; methods of treating certain central nervous system disorders by altering calcium channel activity; and methods of diagnosing diseases associated with particular calcium channels, such as Lambert-Eaton syndrome.
REFERENCES:
patent: 5792846 (1998-08-01), Harpold et al.
Collin, T. et al., "Cloning, Chromosomal Location and Functional Expression of the Human Voltage-Dependent Calcium-Channel .beta.3 Subunit," Eur. J. Biochem. 220: 257-262 (1994).
Williams, M. E. et al., "Structure and Functional Expression of .alpha..sub.1, .alpha..sub.2, and .beta. Subunits of a Novel Human Neuronal Calcium Channel Subtype," Neuron. 8: 71-84 (1992).
Williams, M. D. et al., "Structural and Functional Expression of an .omega.-Conotoxin-Sensitive Human N-Type Calcium Channel," Science 257: 389-395 (1992).
Abstract: Society for Neuroscience, Meeting, Nov. 1994, Miami, FL; Soc. For Neuroscience Abstracts 20: 34.10 (1994).
GenBank Assession #M94172.
GenBank Assession #L27594.
GenBank Assession #M76559.
Chen Ai Ru Sun
Franco Rodrigo
Shuey David John
American Home Products Corp.
Jones W. Gary
Taylor Janell E.
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