Nucleic acid encoding human neuronal calcium channel subunits

Details Nucleic acid encoding human neuronal calcium channel subunits Nucleic acid encoding human neuronal calcium channel subunits

1999-11-30

2000-10-31

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 221, 536 241, 536 243, 536 2433, 435 6, 435 691, 4352402, 435810, 935 77, 935 78, C07H 2102

Patent

active

061404853

ABSTRACT:
Nucleic acids encoding each of three subunits, .alpha.1B, .alpha.2.delta., and .beta.3, of a calcium channel, are disclosed. Also disclosed are vectors containing the nucleic acids encoding the subunits; host cells containing the nucleic acids encoding the subunits; methods of isolating nucleic acids encoding related calcium channel subunits; the subunit proteins; fusion proteins comprising the subunit proteins; antibodies to the subunit proteins; assays to identify agents that modulate calcium channel activity, and agents identified thereby; methods of treating certain central nervous system disorders by altering calcium channel activity; and methods of diagnosing diseases associated with particular calcium channels, such as Lambert-Eaton syndrome.

REFERENCES:
patent: 5792846 (1998-08-01), Harpold et al.
Collin, T. et al., "Cloning, Chromosomal Location and Functional Expression of the Human Voltage-Dependent Calcium-Channel .beta.3 Subunit," Eur. J. Biochem. 220: 257-262 (1994).
Williams, M. E. et al., "Structure and Functional Expression of .alpha..sub.1, .alpha..sub.2, and .beta. Subunits of a Novel Human Neuronal Calcium Channel Subtype," Neuron. 8: 71-84 (1992).
Williams, M. D. et al., "Structural and Functional Expression of an .omega.-Conotoxin-Sensitive Human N-Type Calcium Channel," Science 257: 389-395 (1992).
Abstract: Society for Neuroscience, Meeting, Nov. 1994, Miami, FL; Soc. For Neuroscience Abstracts 20: 34.10 (1994).
GenBank Assession #M94172.
GenBank Assession #L27594.
GenBank Assession #M76559.

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