Nucleic acid encoding human neuronal calcium channel subunits

Details Nucleic acid encoding human neuronal calcium channel subunits Nucleic acid encoding human neuronal calcium channel subunits

1996-09-16

2000-03-21

Sisson, Bradley

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530350, 536 235, 4352523, 4353201, C07H 2102

Patent

active

060404361

ABSTRACT:
Nucleic acids encoding each of three subunits, .alpha.1B, .alpha.2.delta., and .beta.3, of a calcium channel, are disclosed. Also disclosed are vectors containing the nucleic acids encoding the subunits; host cells containing the nucleic acids encoding the subunits; methods of isolating nucleic acids encoding related calcium channel subunits; the subunit proteins; fusion proteins comprising the subunit proteins; antibodies to the subunit proteins; assays to identify agents that modulate calcium channel activity, and agents identified thereby; methods of treating certain central nervous system disorders by altering calcium channel activity; and methods of diagnosing diseases associated with particular calcium channels, such as Lambert-Eaton syndrome.

REFERENCES:
Collin, T., et al., "Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel .beta.3 subunit", Eur. J. Biochem., 220:257-262 (1994).
Williams, M.E., et al., Structure and Functional Expression of .alpha..sub.1, .alpha..sub., and .beta.Subunits of a Novel Human Neuronal Calcium Channel Subtype, Neuron, 8:71-84 (1992).
Williams, M.E., et al., "Structure and Functional Expression of an .omega.-Conotoxin-Sensitive Human N-Type Calcium Channel", Science, 257:389-395 (1992).
Abstract, Society for Neuroscience, Meeting, Nov. 1994, Miami, Florida: Soc. for Neuroscience Abstracts, 20:34.10 (1994).

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