Nucleic acid encoding human neuronal calcium channel subunits

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530350, 536 235, 4352523, 4353201, C07H 2102

Patent

active

060404361

ABSTRACT:
Nucleic acids encoding each of three subunits, .alpha.1B, .alpha.2.delta., and .beta.3, of a calcium channel, are disclosed. Also disclosed are vectors containing the nucleic acids encoding the subunits; host cells containing the nucleic acids encoding the subunits; methods of isolating nucleic acids encoding related calcium channel subunits; the subunit proteins; fusion proteins comprising the subunit proteins; antibodies to the subunit proteins; assays to identify agents that modulate calcium channel activity, and agents identified thereby; methods of treating certain central nervous system disorders by altering calcium channel activity; and methods of diagnosing diseases associated with particular calcium channels, such as Lambert-Eaton syndrome.

REFERENCES:
Collin, T., et al., "Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel .beta.3 subunit", Eur. J. Biochem., 220:257-262 (1994).
Williams, M.E., et al., Structure and Functional Expression of .alpha..sub.1, .alpha..sub., and .beta.Subunits of a Novel Human Neuronal Calcium Channel Subtype, Neuron, 8:71-84 (1992).
Williams, M.E., et al., "Structure and Functional Expression of an .omega.-Conotoxin-Sensitive Human N-Type Calcium Channel", Science, 257:389-395 (1992).
Abstract, Society for Neuroscience, Meeting, Nov. 1994, Miami, Florida: Soc. for Neuroscience Abstracts, 20:34.10 (1994).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acid encoding human neuronal calcium channel subunits does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid encoding human neuronal calcium channel subunits, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid encoding human neuronal calcium channel subunits will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-731429

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.