Nucleic acid encoding human MTS-1 protein

Details Nucleic acid encoding human MTS-1 protein Nucleic acid encoding human MTS-1 protein

1994-01-31

1998-08-25

Hendricks, Keith D.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 435325, 435348, 435419, 4352542, 536 235, C12N 1512, C12N 1581, C12N 1585

Patent

active

057982570

ABSTRACT:
The present invention is directed towards the diagnosis of malignant cancer by detection of the mts-1 mRNA or the mts-1 protein, encoded by the mts-1 gene. The present invention contemplates the use of recombinant mts-1 DNA and antibodies directed against the mts-1 protein to diagnose the metastatic potential of several types of tumor cells, including, for example, thyroid, epithelial, lung, liver and kidney tumor cells. The present invention is also directed to mammalian cell lines and tumors with high and low metastatic potential which have been developed to serve as useful model systems for in vitro and in vivo anti-metastasis drug screening.

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