Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-01-27
1998-12-22
Teng, Sally P.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 43525411, 4353201, 435325, 536 235, C12N 1512, C07K 14705
Patent
active
058517987
ABSTRACT:
Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parlinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
REFERENCES:
Marchese et al., Genomics, 29, 335-344, 1995.
Sambrook et al., Molecular Cloning, vol. 3, 16.2-16.30, 17.2 to 17.28, 1989, Cold Spring Harbor Laboratory Press.
Yamada, Y. et al., "Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase", Molecular Endocrinology, 6(12): 2136-2142, 1992.
Tal, M. et al. "A novel putative neuropeptide receptor expressed in neural tissue, including sensory epithelia", Biochem. and Biophys. Res. Commun., 209(2): 752-759, 1995.
Bergsma Derk
Shabon Usman
Han William T.
King William T.
Prestia Paul F.
SmithKline Beecham Corporation
Teng Sally P.
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