Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-06
1998-05-12
Walsh, Stephen
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 235, 536 231, 530350, 435 691, 435335, 4352523, 4353201, 435 6, 535 52, 436501, C12N 1512, C07H 2100
Patent
active
057503702
ABSTRACT:
A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinson's Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertesnion, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, cyclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.
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Kumar Chandrika
Li Yi
Rosen Craig A.
Human Genome Sciences Inc.
Lazar-Wesley Eliane
Mullins J. G.
Olstein Elliot M.
Walsh Stephen
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