Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-10-09
2007-10-09
Pak, Michael (Department: 1646)
Chemistry: molecular biology and microbiology
Vector, per se
C435S325000, C536S023500
Reexamination Certificate
active
10054616
ABSTRACT:
The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have altered DRY motifs such that the modified GPCRs are constitutively desensitized. As such, the modified GPCRs of the present invention preferably localize to endocytic vesicles or endosomes in an agonist-independent manner. The invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.
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Barak Larry S.
Caron Marc G.
Laporte Stephane A.
Oakley Robert H.
Wilbanks Alyson
Brezner David J.
Dorsey & Whitney
Duke University
Kolman Michael F.
Pak Michael
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