Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-01-03
1998-11-03
Ulm, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 694, 435 711, 4352523, 435325, 4353201, 435 6, C12N 1516, C12N 1563, C12N 121
Patent
active
058310614
ABSTRACT:
Unique ecdysis triggering hormone nucleic acid molecules and ETH peptides/proteins having biological activity for promoting ecdysis in insects are disclosed. Methods of preparing the peptides/proteins by recombinant means, and use of the peptide/proteins in an insect controlling agent are also provided. Methods of inducing ecdysis using the sequences encoding the ETH peptides/proteins are outlined. Insecticidal preparations that are specific to insects that shed their skin, and that do not pose an environmental threat to humans or animals, are also disclosed employing the nucleic and molecules and peptides and proteins they encode. Processes employing the ETH nucleic acid encoding sequences to identify ETH receptors are also defined. The ETH receptors are employed in screening assays to select organic molecules capable of binding the ETH receptor and inducing ecdysis and eclosion, particularly in insects. Methods of using the ETH nucleic acid molecules in genetic engineering of plants and insects are also disclosed.
REFERENCES:
patent: 3941879 (1976-03-01), Okauchi et al.
patent: 5082828 (1992-01-01), Schooley et al.
Kamijo et al. 1990 J. Biol. Chem. 265, 4534.
Anderson et al. In Nucleic Acid Hybridization, B. D. Hames and S. J. Higgins (eds) IRL Press pp. 81-82, 1985.
Akai, H., "Ultrastructure of Epitracheal Gland during Larval-Pupal Molt of Bombyx mori," Cytologia, 57:195-201, 1992.
Hesterlee, Sharon and Morton, David B., "Insect Physiology: The Emerging Story of Ecdysis," Current Biology, 6(6):648-650, 1996.
Maeda et al, "Insecticidal Effects of an Insect-Specific Neurotoxin Expressed by a Recombinant Baculovirus," Virology, 184:777-780, 1991.
Reagan, Jeff D., "Expression Cloning of an Insect Diuretic Harome Receptor: A Member of the Calcitonin/Secretin Receptor Family," Journal of Biological Chemistry, 289(1):9-12, Jan. 1994.
Tomalski, Michael D. and Miller, Lois K., "Insect Paralysis by Baculovirus-Mediated Expression of a Mite Neurotoxin Gene," Nature, 352:82-88, Jul. 1991.
Trimmer, et al, "Purification and Characterization of FMRFamidelike Immunoreactive Substances From the Lobser Nervous System: Isolation and Sequence Analysis of Two Closely Related Peptides," Journal of Comparative Neurology, 266:16-26, 1987.
Truman, James W., "Ecdysis Control Sheds Another Layer," Science, 271:40-41, Jan. 1996.
Zitnan, et al, "Identification of Ecdysis-Triggering Hormone From an Epitracheal Endocrine System," Science, 271:88-91, Jan. 1996.
Adams Michael E.
Gill Sarjeet S.
Zitnan Dusan
Mayfield Denise L.
Pak Michael D.
The Regents of the University of California
Ulm John
LandOfFree
Nucleic acid encoding ecdysis-triggering hormone does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid encoding ecdysis-triggering hormone, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid encoding ecdysis-triggering hormone will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-690723