Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-05-22
2007-05-22
Saoud, Christine J. (Department: 1647)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S253300, C530S350000, C536S023100, C536S024310, C536S024330
Reexamination Certificate
active
10237523
ABSTRACT:
A number of cDNA clones whose products may interact with D1 receptors in vivo were identified. One of the clones, P24, was characterized further. P24 is localized in dendrites and spines of pyramidal cells in PFC. The extent of overlap between P24 expressing and D1 receptor expressing pyramidal cells appeared to be 100%. In contrast, only a limited number D1 receptor antibody labeled neurons in caudate expressed P24. P24 lowers the threshold of D1 receptor response to dopamine (DA) by an order of magnitude. Sequence similarity suggests P24 is a diverged member of the RAMP family. The P24 protein is therefore referred to as a D1 DA RAMP, calcyon. The isolated protein and nucleotide molecule encoding the protein, as well as primers for the nucleotide, are described. The protein and compounds modifying DA binding to the receptor or calcium release which is mediated by the Calcyon, are useful in research studies, drug screening, and therapeutically.
REFERENCES:
patent: 6020143 (2000-02-01), St. George-Hyslop et al.
patent: WO 99/58642 (1999-11-01), None
Wells, J.A. (1990). Additivity of mutational effects in proteins. Biochemistry. 29(37):8509-8517.
Ngo et al. (1994). Computational complexity, protein structure prediction, and the Levinthal paradox. In Merz and Le Grand (Eds.) The Protein Folding Problems and Tertiary Structure Prediction. Birkhauser:Boston, pp. 492-495.
Mikayama et al. (1993). Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor. Proc. Natl. Acad. Sci. USA. 90:10056-10060.
Spiegel, A.M. (1995), Defects in G protein-coupled signal transduction in human disease. Annual Rev. Physiol. 58:143-170.
Pauwels et al. (1998). Review: amino acid domains involved in constitutive activation of G-protein-coupled receptors. Molec. Neurobiol. 17(1-3): 109-135.
Skolnick et al. (2000). From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotech. 18(1):34-39.
Bork, A. (2000). Powers and pitfalls in sequence analysis: the 70% hurdle. Genome Res. 10:398-400.
Doerks et al. (1998). Proteins annotation: detective work for function prediction. Trends in Genetics. 14(6):248-250.
Smith et al. (1997). The challenges of genome sequence annotation or The devil is in the details. Nature Biotech. 15:1222-1223.
Brenner, S.E. (1999). Errors in genome function. Trends in Genetics. 15(4):132-133.
Bork et al. (1996). Go hunting in sequence databases but watch out for the traps. Trends in Genetics. 12(10):425-427.
Lezcano et al. (2000). Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. Science. 287:1660-1664.
Tiberi et al. (1994). High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype. The Journal of Biological Chemistry. 269(45):27925-27931.
Allen, J. B. et al., Finding prospective partners in the library: The two-hybrid system and phage display find a match,TIBS, 20:511-516 (1995).
Artalejo, et al., Activation of facilitation calcium channels in chromaffin cells by D2 dopamine receptors through a cAMPo/protein kinase A- dependent mechanism,Nature, 348(6298):239-242 (1990).
Bergson, C., et al., Characterization of subtype-specific antibodies to the human D5 dopamine receptor: studies in primate brain and transfected mammalian cells,Proc. Natl. Acad. Sci. USA, 92:3468-3472 (1995).
Bergson, et al., Regional, celluylar, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain,J. Neurosci., 15(12):7821-7836 (1995).
Blin, et al., Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor,J. Biol. Chem., 270(30):17741-17748 (1995).
Bluml, et al., Identification of an intracellular tyrosine residue critical for muscarinic receptor-mediated stimulation of phosphatidylinositol hydrolysis,J. Biol. Chem., 269(1):402-405 (1994).
Boehm, et al., Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression,Oncogene, 6(5):695-703 (1991).
Cameron & Williams, Dopamine D1 receptors facility transmitter releast,Nature, 366(6453):344-347 (1993).
Canfield, V. A. and Levenson, R., Transmembrance organization of the Na,K-ATPase determined by epitope addition,Biochemistry, 32:13782-13786 (1993).
Carlock, L., et al., GenEMBL Sequence M98530, The identification of a neuron specific gene that maps adjacent to the Huntington's Disease marker D4S10 that shows homology to protein phosphatase inhibitors, (Mouse 19 kDa protein gene, complete coding sequence).
Casey, Protein lipidation in cell signaling,Science, 268(5208):221-225 (1995).
Cepeda, et al., Differential modulation by dopamine of responses evoked by excitatory amino acids in human cortex,Synapse, 11:330-341 (1992).
Cepeda, et al., Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activiated,Proc. Natl. Acad. SCi. USA, 90(20):9576-9580 (1993).
Chen, et al., One-step transformation of yeast in stationary phase,Curr. Genet., 21(1):83-84 (1992).
Coghlan, et al., Association of protein kinase A and protein phosphatase 2B with a common anchoring protein,Science, 267(5194):108-111 (1995).
Dolph, et al., Arrestin function in inactivation of G protein-coupled receptor rodopsin in vivo,Science, 260:1910-1916 (1995).
Durfee, et al., The retinoblastoma protein associates with protein phosphatase type 1 catalytic subunit,Genes Dev., 7(4):555-569 (1993).
Ellison & See, Rats administered chronic neuroleptics develop oral movements which are similar in form to those in humans with tardive dyskinesia,Psychopharmacology(Berl)., 98(4):564-566 (1989).
Eubanks, et al., Cloning of a novel neuronal dendritic protein that interacts with D1 dopamine receptors,Society for Neuroscience Abstracts, 24:1359 (1998).
Faux & Scott, Molecular glue: kinase anchoring and scaffold proteins,Cell, 85(1):9-12 (1996).
Ferguson, et al., Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization,Science, 271(5247):363-366 (1996).
Fields & Song, a novel genetic system to detect protein-protein interaction,Nature, 340(6230):245-246 (1989).
Formosa, et al., Using protein affinity chromatography to probe structure of protein machines,Methods in Enzymology, 208:24-45 (1991).
Froehner, et al., The submembrane machinery for nicotinic acetylcholine receptor clustering,J. Cell. Biol., 114(1):1-7 (1991).
Fujiwara, T., GenEMBL Sequence D79577, EST HUM282E10B.
Gautam, et al., Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice,Nature, 377(6546):232-236 (1995).
Gill, The enigma of LIM domains,Structure, 3(12):1285-1289 (1995).
Gilmore, et al., Full dopamine D1 agonists in human caudate: Biochemical properties and therapeutic implications,Nueropharmacology, 34(5):481-488 (1995).
Gingrich & Caron, Recent advances in the molecular biology of dopamine receptors,Annu. Rev. Neurosci., 16:299-321 (1993).
Glaser, et al., Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bishosphate in lateral domains,J. Biol. Chem., 271(42):26187-26193 (1996).
Grandy, et al., Multiple Human D5dopamine receptor genes: A functional receptor and two pseudogenes,Proc. Natl. Acad. Sci. USA, 88:9175-9179 (1991).
Grynkiewicz, et al., A new generation of CA2+ indicators with greatly improved fluroscence properties,J. Biol. Chem., 260(6):3440-3450 (1985).
Hamm, The many faces of G protein signaling,J. Biol. Chem., 273(2):669-672 (1998).
Harris & Kater, Dendritic spines: Cellular specializations imparting both stability and flexibility to synaptic function,Annu. Rev. Neurosci., 17:341-371 (1994).
Huang & Kandel, D1/D5 receptor agonists induce a proten synthesis-dependent late potentiation in the CA1 region of the hippocampus,Proc. Natl. Acad. Sci. USA, 92(7):2446-2450 (1995).
Huntley, e
Kilpatrick & Stockton LLP
Lockard Jon M.
Medical College of Georgia Research Institute Inc.
Saoud Christine J.
LandOfFree
Nucleic acid encoding calcyon, a D-1 like dopamine receptor... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid encoding calcyon, a D-1 like dopamine receptor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid encoding calcyon, a D-1 like dopamine receptor... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3766741