Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-04-24
2007-04-24
Mertz, Prema (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S071100, C435S071200, C435S325000, C435S252300, C435S254110, C435S320100, C536S023500
Reexamination Certificate
active
11371157
ABSTRACT:
This invention relates to the diagnosis, treatment and methods for discovery of new therapeutics for atopic asthma and related disorders based on variants of Asthma Associated Factor 2. One embodiment of the invention is a variant of AAF2 wherein codon 173 is deleted resulting in the loss of glutamine 173 from the mature protein precursor. This single amino acid deletion results in a non-functional AAF2 protein and therefore the presence of this phenotype should be associated with less evidence of atopic asthma. Correspondingly, the lack of susceptibility to an asthmatic, atopic phenotype is characterized by the loss of glutamine at codon 171 The invention includes isolated DNA molecules which are variants of the wild type sequence as well as the proteins encoded by such DNA and the use of such DNA molecules and expressed protein in the diagnosis and treatment of atopic asthma.
REFERENCES:
patent: 4761375 (1988-08-01), Clark
patent: 5116951 (1992-05-01), Druez et al.
patent: 5132109 (1992-07-01), Dugas et al.
patent: 5157112 (1992-10-01), van Snick et al.
patent: 5164317 (1992-11-01), Hültner et al.
patent: 5180678 (1993-01-01), Druez et al.
patent: 5208218 (1993-05-01), van Snick et al.
patent: 5246701 (1993-09-01), Dugas et al.
patent: 5414071 (1995-05-01), Yang et al.
patent: A2-0361284 (1990-04-01), None
patent: WO 90/14432 (1990-11-01), None
patent: WO 91/10738 (1991-07-01), None
patent: WO 91/14767 (1991-10-01), None
patent: WO 92/05698 (1992-04-01), None
patent: WO 16/18049 (1993-09-01), None
Aggarwal et al. (1996) Human Cytokines: Handbook for Basic and Clinical Research, Blackwell Scientific Publications, pp. 1-18.
Baker et al. (1996) Allergy and Immunology, J. Am. Med. Assoc. 275:1794-1795.
Borish et al. (1996) Continuing Medical Education: Update on Cytokines, J. Allergy Clin. Immunol. 97:719-734.
Borish et al. (1994) Polymorphisms in the Chromosome 5 Gene Cluster, J. Allergy Clin. Immunol. 93:345.
Busse et al. (1995) Mechanisms of Persistent Airway Inflammation in Asthma, Am. J. Respir. Crit. Care Med. 152:388-393.
Collete et al. (1996) Specific Th1 Cytokine Down-Regulation Associated with Primary Clinically Derived Human Immunodeficiency Virus Type 1NefGene-Induced Expression, J. Immunol. 156:360-370.
De Vita et al. (1995) Local Cytokine Expression in the Progression Toward B Cell Malignancy in Sjögren's Syndrome, J. Rheumatol. 22:1674-1680.
Di Santo et al. (1995) Common Cytokine Receptor γ chain (γc)-Dependent Cytokines: Understandingin vivoFunctions by Gene Targeting, Immunological Review 148:19-34.
Doull et al. (1996) Allelic Association of Gene Markers on Chromosomes 5q and 11q with Atopy and Bronchial Hyperresponsiveness, Am. J. Respir. Crit. Care Med. 153:1280-1284.
Fairman et al. (1995) Physical Mapping of the Minimal Region of Loss in 5q-chromosome, Proc. Natl. Acad. Sci. USA 92:7406-7410.
Finbloom et al. (1995) Induction of Early Response Genes by Interferons, Interleukins, and Growth Factors by the Tyrosine Phosphorylation of Latent Transcription Factors, Arthritis Rheum. 38:877-889.
Finnerty et al. (1996) Effects of Theophylline on Inflammatory Cells and Cytokines in Asthmatic Subjects: A Placebo-Controlled Parallel Group Study, Eur. Respir. J. 9:1672-1677.
Fishman et al. (1996) Molecular Biology of Cytokines in Allergic Diseases and Asthma, Immunol. Allergy Clin. North Am. 16:613-642.
Gotoh et al. (1996) Steel Factor Induces Serine Phosphorylation of Stat3 in Human Growth Factor-Dependent Myeloid Cell Lines, Blood 88:138-145.
Grove et al. (1995) Bronchodilator Subsensitivity to Salbutamol After Twice Daily Salmeterol in Athmatic Patients, Lancet North Am. Ed. 346:201-206.
Gruss et al. (1996) Human Fibroblasts Express Functional IL- Receptors Formed by the IL-2R α- and β- Chain Subunits, J. Immunol. 157:851-857.
Hill et al. (1996) Nitric Oxide Production by the Rat Insulinoma Cell Line, RINm5F Is Specific for IL-1: A Spectrophotometric IL-1 Bioassay, Anal. Biochem. 236:14-19.
Holgate et al. (1995) Genetic and Environmental Influences on Airway Inflammation in Asthma, Int. Arch. Allergy Immunol. 107:29-33.
Horrigan et al. (1996) Polymerase Chain Reaction-Based Diagnosis of Del(5q) in Acute Myeloid Leukemia and Myelodysplstic Syndrome Identifies a Minimal Deletion Inerval, Blood 88:2665-2670.
Kang et al. (1995) Activation of junB and c-myc Primary Response Genes by Interleukin 9 in a Human Factor-Dependent Cell Line, J. Cell. Physiol. 163:623-630.
Kermouni et al. (1995) The IL-9 Receptor Gene (IL9R): Genomic Structure, Chromosomal Localization in the Pseudoautosomal Region of the Long Arm of the Sex Chromosomes, and Identification of IL9R Pseudogenes at 9qter, 10pter, 16pter, and 18pter, Genomics 29:371-382.
Klimka (1996) A Deletion Mutant ofPseudomonasExotoxin-A Fused to Recombinant Human Interleuki-9 (rhIL-9-ETA) Shows Specific Cytotoxicity Against IL-9-Receptor-Expressing Cell Lines, Cytokines Mol. Ther. 2:139-146.
Krishna et al. (1996) Molecular Mediators of Asthma: Current Insights, Hosp. Pract. 31:115-130.
Lemoli et al. (1995) Interleukin-11 (IL-11) and IL-9 Counteract the Inhibitory Activity of Transforming Growth Factor β3 (TGF-β3) on Human Primitive Hematopoietic Progenitor Cells, Haematologica 80:5-12.
Levitt et al. (1988) Expression of airway hyperactivity to acetylcholine as a simple autosomal recessive trait in mice,FASEB2:2605-2608.
Levitt et al. (1994) A Locus Regulating Bronchial Hyperresponsiveness Maps to Chromosome 5q., Am. J. Hum. Genet. 55:1120.
Liles et al. (1995) Review: Nomenclature and Biologic Significance of Cytokines Involved in Inflammation and the Host Immune Response, J. Infect. Dis. 172:1573-1580.
Lopez-Valpuesta et al. (1995) Cytokines and Thermoregulation: Interleukin-9 Injected in Preoptic Area Fails to Evoke Fever in Rats, Brain Res. Bull. 36:181-184.
Macchi et al. (1995) Mutations of Jak-3 Gene in Patients with Autosomal Severe Combined Immune Deficiency (SCID) Nature 337:65-68.
Meyers et al. (1994) Evidence for a Locus Regulating Total Serum IgE Levels Mapping to Chromosome 5, Genomics 23:464-470.
Mossman et al. (1995) Advances in Molecular Genetics, Transgenic Models, and Gene Therapy for the Study of Pulmonary Diseases, Am. J. Respir. Crit. Care Med. 151:2065-2069.
Murahashi et al. (1995) Roles of Stem Cell Factor in theIn VitroGrowth of Blast Clonogenic Cells from Patients with Acute Myeloblastic Leukemia, J. Interferon Cytokine Res. 15:829-835.
Postma et al. (1995) Genetic Susceptibility to Asthma-Bronchial Hyperresponsiveness Coinherited with a Major Gene for Atopy, N. Engl. J. Med. 333:894-900.
Reinecker et al. (1995) Human Intestinal Epithelial Cells Express Functional Cytokine Receptors Sharing the Common γc Chain of the Interleukin 2 Receptor, Proc. Natl. Acad. Sci. USA 92:8353-8357.
Remick (1995) Cytokines: A Primer for Platic Surgeons, Ann. Plast. Surg. 35:549-559.
Renauld (1995) Interleukin-9: Structural Characteristics and Biologic Properties, Cytokines: Interleukins and Their Receptors, 80:287-303.
Renauld et al. (1995) Interleukin-9 and its Receptor: Involvement In Mast Cell Differentiation and T cell Oncogenesis, J. Leukoc. Biol. 57:353-360.
Renauld et al. (1990) Expression in Activated CD4+T cells, Genomic Organization, and Comparison with Mouse Gene, J. Immunol. 144:4235-4241.
Renauld et al. (1992) Expression Cloning of the Murine and Human Interleukin-9 Receptor cDNAs, Proc. Natl. Acad. Sci. USA 89:5690-5694.
Rosenwasser et al. (1995) Transcriptional Regulation of the Human IL-4 Gene in Atopy and Asthma, J. Invest. Med. 43:326.
Rosenwasser et al. (1994) Transcriptional Regulation of Human IL-4, J. Allergy Clin. Immunol. 93:599.
Rusten et al. (1996) The RAR-RXR as Well as the RXR-RXR Pathway is Involved in Signaling Growth Inhibition of Human CD34+Erythroid Progenitor Cells, Blood 87:1728-1736.
Schumann et al. (1996) Transcript Synthesis and Surface Expression of the Interleukin-2 Reception (α-, β-, and γ- chain) by Normal and Malignant Myeloid Cells, Blood 87:2419-2427.
Sun et al. (1995) Role of the IRS-2 in Insulin and Cytokine
Grasso Luigi
Holroyd Kenneth J.
Levitt Roy Clifford
Nicolaides Nicholas C.
Genaera Corporation
Mertz Prema
Morgan & Lewis & Bockius, LLP
LandOfFree
Nucleic acid encoding an interleukin-9 receptor variant does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid encoding an interleukin-9 receptor variant, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid encoding an interleukin-9 receptor variant will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3799958