Nucleic acid encoding an antibody that inhibits cell adhesion pr

Details Nucleic acid encoding an antibody that inhibits cell adhesion pr Nucleic acid encoding an antibody that inhibits cell adhesion pr

1995-06-05

1998-09-01

Hutlell, Paula K.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353251, 536 2353, 536 234, 536 231, 5303873, 5303881, 5303871, C12N 120, C07H 2104

Patent

active

058010440

ABSTRACT:
Disclosed is a method of inhibiting the binding of a cell bearing a cell adhesion protein to a molecule or cell bearing a carbohydrate determinant specific for the cell adhesion molecule. The method involves contacting the cell adhesion protein-bearing cell with an inhibitor molecule bearing the carbohydrate determinant. Also disclosed is a method of inhibiting the binding of the first member of a specific binding pair to the second member of the specific binding pair, involving contacting the first member with an antibody which is specific for the first member and which is covalently bonded to a carbohydrate moiety which interferes with the antibody's ability to fix complement and bind an F.sub.c receptor. The methods of the invention may be used, for example, to reduce inflammation.

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