Nucleic acid encoding an altered telomere repeat binding factor

Details Nucleic acid encoding an altered telomere repeat binding factor Nucleic acid encoding an altered telomere repeat binding factor

1998-12-11

2000-02-08

McKelvey, Terry

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435243, 4352523, 4353201, 435325, 435410, 536 231, 536 235, C12P 2102, C12N 100, C12N 510, C12N 1512, C12N 1563

Patent

active

060227095

ABSTRACT:
The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRF) that hinders the binding of a TRF to its specific telomere repeat sequence. Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.

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