Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-09
1999-11-30
Sidberry, Hazel F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 221, 536 237, 4352523, 4353201, 435 691, 435 693, 435 711, 435 712, 4242561, C07H 2404, C12N 121, C12N 1531, A61K 39102
Patent
active
059945257
ABSTRACT:
The invention provides a vaccine for the prevention and/or the treatment of infection by Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, which vaccine contains at least an immunogenic part of at least one cytolytic protein of A. pleuropneumoniae produced by recombinant DNA, and detoxified derivatives thereof. Three of such cytolytic proteins are identified and a vaccine containing these, or parts or derivatives thereof, ensures protection against all known serotypes of A. pleuropneumoniae. The cytolytic proteins are produced by inserting a nucleotide sequence encoding one or more of the proteins or parts thereof in a host cell, cultivating the host cell and recovering the proteins. another vaccine contains the genetic information for one or more of the cytolytic proteins, and a passive vaccine contains antibodies against these proteins. The invention further provides monoclonal antibodies and DNA probes for use in diagnostics.
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Kamp Elbarte Margriet
Smits Marinus Adrianus
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