Nucleic acid encoding a transiently-expressed kinetochore protei

Details Nucleic acid encoding a transiently-expressed kinetochore protei Nucleic acid encoding a transiently-expressed kinetochore protei

1994-12-09

1997-02-04

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4351723, 935 9, C12N 1512, C12N 1500

Patent

active

055999190

ABSTRACT:
An isolated nucleic acid is provided which encodes a transiently-expressed kinetochore protein, CENP-F. Also provided are the purified polypeptide encoded by the nucleic acid sequence, and antibodies immunologically specific for the polypeptide. These biological molecules are useful as markers of cellular proliferation, particularly for the identification of cells in the G2 and M phases of the cell cycle. Methods are provided for using the nucleic acid, protein and antibodies for assessing cellular proliferation in biological fluids and tissue samples, and for detecting the presence of autoantibodies to the protein.

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