Nucleic acid encoding a subunit of Na + ,K + -ATPase

Details Nucleic acid encoding a subunit of Na + ,K + -ATPase Nucleic acid encoding a subunit of Na + ,K + -ATPase

2009-11-25

2010-11-09

Fronda, Christian L (Department: 1652)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S183000, C435S195000, C435S252300, C435S320100

Reexamination Certificate

active

07829686

ABSTRACT:
A recombinant Na+, K+-ATPase α1-subunit protein resistant to cardiac glycosides, e.g. oubain, is disclosed, as well as methods for its production and use. The resistance to cardiac glycosides are obtained by alterations in the region situated between and including the amino acids 65-133. Such recombinant protein and nucleic acid constructs expressing the same are useful as selection markers in gene therapy and research applications.

REFERENCES:
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