Nucleic acid encoding a stress-responsive subunit of human RNA p

Details Nucleic acid encoding a stress-responsive subunit of human RNA p Nucleic acid encoding a stress-responsive subunit of human RNA p

1995-01-20

1998-06-23

Hendricks, Keith D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435194, 536 241, 536 2433, 536 2431, C12N 912, C12N 1554

Patent

active

057707170

ABSTRACT:
An isolated nucleic acid is provided, which encodes a stress-responsive subunit of mammalian RNA polymerase II, RPB4. In a preferred embodiment, the human RPB4 subunit (hsRPB4) is provided. Also provided are oligonucleotides that specifically hybridize with the nucleic acid, the purified polypeptide encoded by the nucleic acid and antibodies immunologically specific for the polypeptide. These biological molecules are useful as markers of stress-related responses, which may correspond to the occurrence of malignant disease, and as therapeutic agents to modify resistance of a selected cell population to external stress conditions, such as that resulting from treatment of a patient with chemotherapeutic agents.

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