Nucleic acid encoding a polypeptide with the biological...

Details Nucleic acid encoding a polypeptide with the biological... Nucleic acid encoding a polypeptide with the biological...

2007-12-04

2010-02-16

Fronda, Christian L (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S183000, C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

07662603

ABSTRACT:
The present invention relates to serine hydroxymethyltransferase (E.C. 2.1.2.1) as novel target for herbicides, and to nucleic acid sequences encoding a polypeptide with the biological activity of a serine hydroxymethyltransferase, which, when not present, bring about growth retardation symptoms and chlorotic leaves, comprising the nucleic acid sequence SEQ ID No:3, and functional equivalents of the abovementioned nucleic acid sequence or the nucleic acid sequence SEQ ID NO:7 and functional equivalents of the abovementioned nucleic acid sequence. Moreover, the present invention relates to the use of the abovementioned nucleic acid sequences, of functional analogs of the SEQ ID NO:3 or SEQ ID NO:7 or of polypeptides encoded by one of the abovementioned nucleic acid sequences in a method for identifying herbicidally active compounds which inhibit serine hydroxymethyltransferases, and to the use of these compounds which have been identified by the method as herbicides.

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Biosis, Biosciences Information Service, Philadelphia, PA, US; 1982 Peterson R B: “Regulation of Glycine Decarboxylase and L Serine Hydroxymethyl Transferase Activities by Glyoxylate in Tobacco NicotianaTabacum Cultivar, John-Williams-Broadleaf Leaf Mitochondrial, Preparations”, Database accession No. PREY 198375052588, XP002250319, & Plant Physiology (Bethesda), vol. 70, No. 1, 1982,p. 61-66.

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