Nucleic acid encoding a polypeptide promoting type II...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

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C435S410000, C435S252300, C435S254110, C435S320100, C435S226000, C536S023200, C536S023500

Reexamination Certificate

active

07125715

ABSTRACT:
A novel polypeptide, a polynucleotide encoding this polypeptide, an expression vector comprising this polynucleotide, a cell transfected with the expression vector, and a pharmaceutical composition for promoting type II collagen production, a pharmaceutical composition for promoting aggrecan production, and a pharmaceutical composition for treating and/or preventing osteoarthritis comprising the above polypeptide as an active ingredient are disclosed. The polypeptide exhibits an activity of promoting type II collagen production and/or an activity of promoting aggrecan production.

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