Nucleic acid encoding a poly-(ADP) ribose polymerase enzyme...

Details Nucleic acid encoding a poly-(ADP) ribose polymerase enzyme... Nucleic acid encoding a poly-(ADP) ribose polymerase enzyme...

2003-07-31

2008-07-22

Hutson, Richard G (Department: 1652)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S194000, C536S023500, C536S023100

Reexamination Certificate

active

07402665

ABSTRACT:
Poly(ADP)-ribose polymerase (PARP) becomes activated at sites of DNA damage and is thought to promote repair by modifying local chromatin proteins and transcription factors. Disclosed is an isoform of PARP, PARP-e, which lacks enzymatic function and which is encoded by a gene having a novel structure. Also disclosed are methods of modulating chromatin structure resulting in modulation of gene activation, gene repression and chromatin condensation and decondensation.

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