Nucleic acid encoding a pig heat shock protein 70

Details Nucleic acid encoding a pig heat shock protein 70 Nucleic acid encoding a pig heat shock protein 70

2007-07-03

2007-07-03

Bertoglio, Valarie (Department: 1632)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C800S013000, C800S014000, C800S017000

Reexamination Certificate

active

11073579

ABSTRACT:
The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can be used in the production of HSP in large quantities, as a xenograft source for transplation and as an animal model close to human for illustrating the protective roles of HSP. Furthermore, the transgenic pig of the invention has a better meat quality and exhibits an increased growth rate and a reduced backfat thickness.

REFERENCES:
Peelman, LJ et al., Complete nucleotide sequence of a porcine HSP70 gene, Immunogenetics, 1992, 35:286-289.
Chen, Ming-Yu, Partial Abstracts of the 5thConference of the Asia-Pacific International Molecular Biology Network (A-IMBN)(Part I): Augmentation of thermotolerance in primary skin fibroblasts from a transgenic pig overexpressing the porcine HSP70.2,Acta Biochimica et Biophysica Sinica 35(2): 198, 2003.
Chen, Ming-Yu, “Augmentation of thermotolerance in primary skin fibroblasts from a transgenic pig overexpressing the porcine HSP70.2”,Asian-Australia Journal of Animal Sciences, 18(1): 107-112, 2005.
Kiang, J.G., et al., “Heat Shock Protein 70 kDa: Molecular Biology, Biochemistry, and Physiology”Pharmacol. Ther., 1998, pp. 183-201, vol. 80, No. 2, Elsevier Science Inc., Washington, D.C.
Marber, M.S., et al., “Overexpression of the Rat Inducible 70-kD Heat Stress Protein in a Transgenic Mouse Increases the Resistance of the Heart to Ischemic Injury”,J. Clin. Invest, Apr. 1995, pp. 1446-1456, vol. 95, The American Society for Clinical Investigation. Inc.
Mirkes, P.E., et al., “Heat Shock Protein 70 (Hsp70) Protects Postimplantation Murine Embryos From the Embryolethal Effects fo Hypertherthermia”Developmental Dynamics, 1999, pp. 159-170, vol. 214, Wiley-Liss, Inc.
Plumier, J.C. et al., “Transgenic Mice Expressing the Human Heat Shock Protein 70 Have Improved Post-Ischemic Myocardial Recovery”,J. Clin. Invest., Apr. 1995, pp. 1854-1860, vol. 95, The American Society for Clinical Investigation. Inc.

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