Nucleic acid encoding a novel P-selectin ligand protein

Details Nucleic acid encoding a novel P-selectin ligand protein Nucleic acid encoding a novel P-selectin ligand protein

1995-04-25

1998-12-01

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352402, 4352523, 43525411, 4353201, 536 235, C12N 1512, C12N 1585

Patent

active

058437070

ABSTRACT:
A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.

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