Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-06-06
2000-03-21
Sisson, Bradley L.
Chemistry: molecular biology and microbiology
Vector, per se
536 243, C12N 1500, C07H 2104
Patent
active
060401737
ABSTRACT:
Three mammalian proteins are disclosed which are useful in the diagnosis and prognosis of tumors of lymphoid and epithelial origin. The three proteins are immunologically related to each other. The level of expression of the proteins correlates with the malignant potential of lymphoid and epithelial tumors. In addition, in some cases the subcellular location of the proteins is indicative of malignant potential. Antibodies reactive with the proteins are disclosed as diagnostic tools, as are nucleic acid probes and primers for quantitating the messenger RNAs encoding the proteins. Methods for preparing and purifying the proteins are also taught.
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Johns Hopkins University
Sisson Bradley L.
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