Nucleic acid encoding a novel human EP prostaglandin receptor

Chemistry: molecular biology and microbiology – Spore forming or isolating process

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4352523, 43525411, 435 691, 536 235, C12N 1512

Patent

active

057168350

ABSTRACT:
A gene encoding the HP4 human prostaglandin receptor is disclosed. The protein encoded by this gene exhibits significant sequence identity with other prostaglandin receptors. The HP4 receptor, when expressed in eukaryotic cells, is capable of binding prostaglandins and their analogs and stimulating adenylate cyclase activity in response to prostaglandins.

REFERENCES:
Bastien, Lison et al.; The Journal of Biological Chemistry; col. 269, No. 16, Apr. 22, pp. 11873-11877, 1994; "Cloning, Functional Expression, and Characterization of the Human Prostaglandin E2 Receptor EP2 Subtype".
1994 Receptor & Ion Channel Nomenclature Supplement; Trends in Pharmacological Sciences; Fifth Edition; p. 6.
An, S. et al., Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. Biochemical and Biophysical Research Communications 197:263-270 (1993).
Colman, R.A., Eicosanoids and other bioactive lipids in cancer, inflammation and radiation injury. Nigam, S. et al. eds. 135-151 (1991).
Coleman, R.A. et al., A novel inhibitory prostanoid receptor in piglet saphenous vein. Prostaglandins 47:151-168 (1994).
Dong, Y.J. et al., Prostaglandin E receptor subtypes in smooth muscle: agonist activities of stable prostacyclin analogues. Br. J. Pharmacol. 87:97-107 (1986).
Funk, C.D. et al., Cloning and expression of a cDNA for the human prostaglandin E receptor EP.sub.1 Subtype. J. Biol. Chem. 268(35):26767-26772 (1993).
Gardiner, P.J., Characterization of prostanoid relaxant/inhibitory receptors using a highly selective agonist, TR4979. Br. J. Pharmacol. 87:45-56 (1986).
Giles, H., More selective ligands at eiconsanoid receptor subtypes improve prospects in inflammatory and cardiovascular research. Trends Pharm. Sci. 11:301-304 (1990).
Hebert, R.L. et al., PGE.sub.2 inhibits AVP-induced water flow in cortical collecting ducts by protein kinase C activation. Am. J. Physiol. 259:F318-F325 (1990).
Hirata, M. et al., Cloning and expression of cDNA for a human thromboxane A.sub.2 receptor. Nature 349:617-620 (1991).
Honda, A. et al., Cloning and expression of a cDNA for mouse prostaglandin E receptor EP.sub.2 subtype. J. Biol. Chem. 268(11):7759-7762 (1993).
Humbles, A.A. et al., Pharmacological characterisation of the protanoid receptors in the rabbit isolated ear artery. Br. J. Pharmacol. 108:74P (1993).
Milne, S.A. et al., Furthur investigation of prostanoid EP receptors in rabbit jugular and pig saphenous veins. Br. J. Pharmacol. III:79P (1994).
Nials, A.T. et al., AH13205, a selective prostanoid EP.sub.2 -receptor agonist. Cardiovascular Drug Reviews 11(2):165-179 (1993).
Regan, J.W. et al., Molecular cloning and expression of human EP.sub.3 receptors: evidence of three variants with differing carboxyl termini. Br. J. Pharmacol. 112:377-385 (1994).
Senior, J. et al., In vitro characterization of prostanoid EP-receptors in the non-pregnant human myometreium. Br. J. Pharmacol. 102:747-753 (1991).
Smith, W.L., Prostanoid biosynthesis and mechanisms of action. Am. J. Physiol. 263:F181-F191 (1992).
Sonnenburg, W.K. and Smith, W.L., Regulation of cyclic AMP metabolism in rabbit cortical collecting tubule cells by prostaglandins. J. Biol. Chem. 263(13):6155-6160 (1988).
Sugimoto, Y. et al., Cloning and expression of a cDNA for mouse prostaglandin E receptor EP.sub.3 Subtype. J. Biol Chem. 267(10):6463-6466 (1992).
Woodward, D.F. et al., Identification of 19 (R)-OH prostaglandin E.sub.2 as a selective prostanoid EP.sub.2 -receptor agonist. Postaglandins 46:371-383 (1993).
Yeardley, H.L. et al., The effects of spasmolytic and spasmogenic prostanoids on cyclic amp levels in human myometrium from pregnant donors. Br. J. Pharmacol. Proc. Suppl. 108:174p (1992).
Katsuyama et al., FEBS Letters, vol. 344, p. 74, 1994.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acid encoding a novel human EP prostaglandin receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid encoding a novel human EP prostaglandin receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid encoding a novel human EP prostaglandin receptor will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2076537

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.