Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-06
1998-05-26
Walsh, Stephen
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 235, 536 231, 530350, 4353201, 4352523, 435325, C12N 1512, C07H 2100
Patent
active
057563098
ABSTRACT:
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
REFERENCES:
Buck et al, Cell 65:175-187, 1991.
Li Yi
Rosen Craig A.
Ruben Steven M.
Soppet Daniel R.
Human Genome Sciences Inc.
Lazar-Wesley Eliane
Mullins J. G.
Olstein Elliot
Walsh Stephen
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