Nucleic acid encoding a haplotype of human T2R receptor hT2R50

Details Nucleic acid encoding a haplotype of human T2R receptor hT2R50 Nucleic acid encoding a haplotype of human T2R receptor hT2R50

2007-09-05

2010-10-12

Landsman, Robert (Department: 1647)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S252300, C435S320100, C435S325000, C435S471000, C536S023500

Reexamination Certificate

active

07811788

ABSTRACT:
The present invention relates to the discovery of a novel haplotype of the human taste receptor hT2R50 in the T2R taste receptor family that responds to particular bitter ligands, i.e., 2-acetylpyrazine and ethylpyrazine. The present invention also relates to the use of this novel haplotype in assays for identifying ligands that modulate the activation of the hT2R50 taste receptor. These compounds potentially may be used as additives in foods, beverages and medicinals for modifying (blocking) hT2R50-associated bitter taste.

REFERENCES:
patent: 7368531 (2008-05-01), Rosen et al.
patent: 7411051 (2008-08-01), Rosen et al.
patent: 7413867 (2008-08-01), Bufe et al.
patent: 2002/0094551 (2002-07-01), Adler
patent: 2005/0048586 (2005-03-01), Zuker et al.
patent: 2004029087 (2004-04-01), None
patent: 2005007891 (2005-01-01), None
Accession No. AY677149, Oct. 18, 2004.
Christopher M. Parry, et al., Divergence of T2R chemosensory receptor families in humans, bonobos, and chimpanzees; Proceedings of the National Academy of Sciences of the United States of America, Oct. 12, 2004, vol. 101, No. 41, pp. 14830-14834.
C. Conte, et al., Identification and characterization of human taste receptor genes belonging to the TAS2R family, Cytogeneric and Genome Reseach, Jan. 1, 2002, vol. 98, No. 1, pp. 45-53.
Unkyung Kim, et al., Worldwid Haplotype Diversity and Coding Sequence Variation at Human Bitter Taste Receptor Loci, Human Mutation, Sep. 1, 2005, vol. 26, No. 3., pp. 199-204.
Kazuko Shimazaki, et al., Evaluation of the odor activity of pyrazine derivatives using structural and electronic parameters derived from conformational study by molecular mechanics (MM3) and ab initio calculations, Journal of Molecular Structure 749 (2005) pp. 169-176.
European Search Report Mar. 1, 2010 (EP App. No. 07837699.3).

Affiliated with

Also associated with

Rating

Nucleic acid encoding a haplotype of human T2R receptor hT2R50 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid encoding a haplotype of human T2R receptor hT2R50, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid encoding a haplotype of human T2R receptor hT2R50 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4191529