Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1999-01-28
2000-06-13
Mertz, Prema
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 711, 435 712, 4352523, 43525411, 4353201, 435325, 435471, 536 231, 536 235, 536 243, 536 2431, 536 245, 530350, C12N 1512, C12N 510, C12N 1563, C07K 14705
Patent
active
060748451
ABSTRACT:
BECRLR polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing BECRLR polypeptides and polynucleotides in screening assays to discover compounds that either agonize or antagonize the biological activity of the receptor. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome.
REFERENCES:
Cunningham et al. (1989) Science, vol. 24,4 pp. 1081-1085.
George et al. (1988) Macromolecular Sequencing & Synthesis Selected Methods and Applications, pp. 127-149, ch, 12, Alan R. Liss, Inc.
Fluhmann et al. (1995) Biochemical & Biophysical Research Communcations, vol. 206, No. 1, pp. 341-367.
Aiyar, et al. "A cDNA Encoding the Calcitonin Gene-related Peptide Type 1 Receptor", The Journal of Biological Chemistry, vol. 271 (19) pp. 11325-11329 (1996).
GenBank Accession No. L76380. Aiyar et al. Aug. 13, 1996.
Aiyar Nambi V.
Disa Jyoti
Hecht Elizabeth J.
King William T.
Mertz Prema
SmithKline Beecham Corporation
LandOfFree
Nucleic acid encoding a bovine calcitonin receptor-like receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid encoding a bovine calcitonin receptor-like receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid encoding a bovine calcitonin receptor-like receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2067516