Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-04-26
2011-04-26
Whisenant, Ethan (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024300
Reexamination Certificate
active
07932039
ABSTRACT:
The present invention provides methods, compositions, and kits for detecting the presence or absence of target sequences in a sample, where the sample also contains interfering sequences that are similar or identical to the target sequences. In particular, the present invention provides blocker oligonucleotides that at least partially inhibit the formation of invasive cleavage structures with the interfering sequences but do not substantially inhibit the formation of invasive cleavage structures with the target sequences.
REFERENCES:
patent: 5001050 (1991-03-01), Blanco
patent: 5198543 (1993-03-01), Blanco
patent: 5614402 (1997-03-01), Dahlberg
patent: 5795763 (1998-08-01), Dahlberg
patent: 5843669 (1998-12-01), Kaiser
patent: 5846717 (1998-12-01), Brow
patent: 5985557 (1999-11-01), Prudent
patent: 5994069 (1999-11-01), Hall
patent: 6001567 (1999-12-01), Brow
patent: 6001983 (1999-12-01), Benner
patent: 6090543 (2000-07-01), Prudent
patent: 6090606 (2000-07-01), Kaiser
patent: 6117634 (2000-09-01), Langmore
patent: 6183960 (2001-02-01), Lizardi
patent: 6194149 (2001-02-01), Neri
patent: 6197557 (2001-03-01), Makarov
patent: 6210884 (2001-04-01), Lizardi
patent: 6235502 (2001-05-01), Weissman
patent: 6291187 (2001-09-01), Kingsmore
patent: 6323009 (2001-11-01), Lasken
patent: 6528254 (2003-03-01), Sorge
patent: 6589743 (2003-07-01), Sorge
patent: 6627159 (2003-09-01), Bedingham
patent: 6692917 (2004-02-01), Neri
patent: 6720187 (2004-04-01), Bedingham
patent: 6734401 (2004-05-01), Bedingham
patent: 6814935 (2004-11-01), Harms
patent: 6872816 (2005-03-01), Hall
patent: 6875572 (2005-04-01), Prudent
patent: 6913881 (2005-07-01), Aizenstein
patent: 7026168 (2006-04-01), Bedingham
patent: 7045289 (2006-05-01), Allawi
patent: 7060436 (2006-06-01), Lyamichev
patent: 7122364 (2006-10-01), Lyamichev
patent: 7150982 (2006-12-01), Allawi
patent: 7189508 (2007-03-01), Sorge
patent: 7195871 (2007-03-01), Lyamichev
patent: 7256020 (2007-08-01), Lyamichev
patent: 7303869 (2007-12-01), Stevens
patent: 7482127 (2009-01-01), Agarwal et al.
patent: WO97/27214 (1997-07-01), None
patent: WO98/23774 (1998-06-01), None
patent: WO98/39485 (1998-09-01), None
patent: WO98/42873 (1998-10-01), None
patent: WO98/050403 (1998-11-01), None
patent: WO01/88190 (2001-11-01), None
patent: WO01/90337 (2001-11-01), None
patent: WO01/98537 (2001-12-01), None
patent: WO02/00934 (2002-01-01), None
patent: WO02/070755 (2002-09-01), None
patent: WO03/073067 (2003-09-01), None
Els et al., An invasive cleavage assay for direct quantitation of specific RNAs. Nature Biotechnology 19 : 673-676 (2001).
Ledford et al., a Multi-Site Study for Detection of the Factor V (Leiden) Mutation from Genomic DNA Using a Homogeneous Invader Microtiter Plate Fluorescence Resonance Energy Transfer (FRET) Assay. Journal of Molecular Diagnostics 2(2) : 97-104 (2000).
Lyamichev, et al., “Experimental and theoretical analysis of the invasive signal amplification reaction” Biochemistry 39:9523-9532 (2000).
Allawi, et al. “Thermodynamics and NMR of internal G.T mismatches in DNA” Biochemistry. Aug. 26, 1997;36 (34):10581-94.
Anderson, et al. “Quantitative Filter Hybridization” Nucleic Acid Hybridization (1985) Chapter 4, pp. 73-111.
Doty, et al. “Strand Separation and Specific Recombination in Deoxyribonucleic Acids: Physical Chemical Studies” Proc Natl Acad Sci U S A. Apr. 1960;46(4):461-76.
Hall, et al. “Sensitive detection of DNA polymorphisms by the serial invasive signal amplification reaction” Proc Natl Acad Sci U S A. Jul. 18, 2000;97(15):8272-7.
Kong, et al. “Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues” Nucleic Acids Res. vol. 17pp. 10373-10383, (1989).
Kong, et al. “Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction” Nucl. Acid. Res. vol. 20 pp. 5149-5152, ( 1992).
Lennard, et al., “Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia” Lancet, 336:225-229, 1990.
Lyamichev, et al. “Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes” Nat Biotechnol. Mar. 1999;17(3):292-6.
Marmur, et al. “Strand Separation and Specific Recombination in Deoxyribonucleic Acids: Biological Studies” Proc Natl Acad Sci U S A. Apr. 1960;46(4):453-61.
Reynaldo, et al. “The kinetics of oligonucleotide replacements” J Mol Biol. Mar. 24, 2000 vol. 297(2) pp. 511-520.
Schweitzer, et al. “Aromatic Nonpolar Nucleosides as Hydrophobic Isoteres of Pyrimidine and Purine Nucleosides” J. Org. Chem., 1994, 59, 7238-7242.
Schweitzer, et al. “Hydrophobic, Non-Hydrogen-Bonding Bases and Base Pairs in DNA” J. Am. Chem. Soc., 1995, 117, 1863-1872.
Selvin “Fluorescence resonance energy transfer” Methods Enzymol. 1995;246:300-34.
Stryer “Fluorescence energy transfer as a spectroscopic ruler” Annu Rev Biochem. 1978;47:819-46.
Tyagi, et al. “Wavelength-shifting molecular beacons” Nat Biotechnol. Nov. 2000;18(11):1191-6.
Agarwal Poonam
Kwiatkowski, Jr. Robert W.
Casimir Jones S.C.
Third Wave Technologies Inc.
Whisenant Ethan
LandOfFree
Nucleic acid detection assays employing blocker... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid detection assays employing blocker..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid detection assays employing blocker... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2637579