Nucleic acid derivatives

Details Nucleic acid derivatives Nucleic acid derivatives

2006-03-02

2008-03-25

Riley, Jezia (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C536S023100, C536S024300, C536S024330

Reexamination Certificate

active

07348148

ABSTRACT:
A compound which comprises a backbone having a plurality of chiral carbon atoms, the backbone bearing a plurality of ligands each being individually bound to a chiral carbon atom of the plurality of chiral carbon atoms, the ligands including one or more pair(s) of adjacent ligands each containing a moiety selected from the group consisting of a naturally occurring nucleobase and a nucleobase binding group, wherein moieties of the one or more pair(s) are directly linked to one another via a linker chain; building blocks for synthesizing the compound; and uses of the compound, particularly in antisense therapy.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 5908845 (1999-06-01), Segev
patent: 7034131 (2006-04-01), Segev
patent: 2003/0191074 (2003-10-01), Segev
patent: WO86/05518 (1986-09-01), None
patent: WO86/05519 (1986-09-01), None
patent: WO89/12060 (1989-12-01), None
patent: WO92/20702 (1992-11-01), None
patent: WO01/16365 (2000-07-01), None
patent: WO 02/061110 (2002-08-01), None
Calabretta et al. “Normal and Leukemic Hematopoietic Cell Manifest Differential Sensitivity to Inhibitory Effects of C-myc Antisense Oligodeoxynucleotides: An In Vitro Study Relevant to Bone Marrow Purging”, Proc. Natl. Acad. Sci. USA, 88: 2351-2355, 1991.
Burch et al. “Oligodeoxynucleotides Antisense to the Interleukin 1 Receptor mRN Block the Effects of Interleukin 1 in Cultured Murine and Human Fibroblasts and in Mice”, J. Clin. Invest., 88: 1190, 1991. Abstract.
Agrawal “Antisense Oligonucleotides as Antiviral Agents”, Trends Biotechnol., 10(5): 152-158, 1992. Abstract.
Uhlmann et al. “Antisense Oligonucleotides: A New Therapeutic Principle”, Chemical Reviews, 90(4): 543-584, 1990.
Fodor et al. “Light-Directed, Spatially Addressable Parallel Chemical Synthesis”, Science, 251(4995): 767-773, 1991.
Viari et al. “Plasma Desorption Mass Spectrometric Study of UV-Induced Lesions Within DNA Model Compounds”, Biomedical and Environmental Mass Spectrometry, 18(8): 547-552, 1989. & 7th International Symposium on Mass Spectrometry in Life Sciences, Gent, B, 1988. p. 548, Fig.1.
Kikuta et al. “A New Type of Potent Inhibitors of HIV-1 TAR RNA—Tat Peptide Binding by Zinc(II)—Macrocyclic Tetraamine Complexes”, Journal of the American Chemical Society, 123(32): 7911-7912, 2001. p. 7912, Scheme 1, Last §, p. 7911, Last §.
Faria et al. “Phosphoramidate Oligonucleotides as Potent Antisense Molecules in Cells and In Vivo”, Nature Biotechnology, 19: 40-44, 2001. Abstract.
Heikkila et al. “A C-Myc Antisense Oligodeoxynucleotide Inhibits Entry Into S Phase But Not Progress From G0 to G1”, Nature, 328(6129); 445-449, 1987. Abstract.
Meyer et al. “Efficient, Specific Cross-Linking and Cleavage of DNA by Stable, Synthetic Complementary Oligodeoxynucleotides”, Journal of the American Chemical Society, 11: 8517-8519, 1989. Abstract.

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