Nucleic acid derivatives

Details Nucleic acid derivatives Nucleic acid derivatives

2006-04-25

2006-04-25

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024300, C536S025300, C536S025320, C514S001000, C514S04400A, C435S006120, C435S128000

Reexamination Certificate

active

07034131

ABSTRACT:
A compound which comprises a backbone having a plurality of chiral carbon atoms, the backbone bearing a plurality of ligands each being individually bound to a chiral carbon atom of the plurality of chiral carbon atoms, the ligands including one or more pair(s) of adjacent ligands each containing a moiety selected from the group consisting of a naturally occurring nucleobase and a nucleobase binding group, wherein moieties of the one or more pair(s) are directly linked to one another via a linker chain; building blocks for synthesizing the compound; and rises of the compound, particularly in antisense therapy.

REFERENCES:
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patent: 5908845 (1999-06-01), Segev
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patent: WO86/05519 (1986-09-01), None
patent: WO89/12060 (1989-12-01), None
patent: WO92/20702 (1992-11-01), None
patent: WO01/16365 (2000-07-01), None
Uhlmann et al. Chemical Reviews, vol. 90, No. 4, Jun. 1990, pp. 543-584.

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