Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Reexamination Certificate
2006-05-25
2008-12-09
Vogel, Nancy (Department: 1636)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
C435S320100, C424S093100
Reexamination Certificate
active
07462351
ABSTRACT:
The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced delivery of nucleic acids, particularly eucaryotic expression vectors, demonstrate enhanced delivery of nucleic acids to cells in vivo. The present invention also provides methods of treatment in combination with such formulations.
REFERENCES:
patent: 5877302 (1999-03-01), Hanson et al.
patent: 6066468 (2000-05-01), Burnham et al.
patent: 2003/0039960 (2003-02-01), Conroy et al.
patent: 2003/0064949 (2003-04-01), Nielsen et al.
patent: 0935967 (1998-10-01), None
patent: 2207050 (1989-01-01), None
patent: WO 01/12231 (2001-02-01), None
Conroy, Susan, et al.; “In Vitro Vector Stability and Fluid Dynamics of an Intraperitoneal Solution for Delivery of Gene Therapy;” Proceedings of the American Association for Cancer Research, Mar. 2002; vol. 41; p. 524.
Engler, Heidrun, et al.; “Enhancement of Intraperitoneal Adenovirus Mediated Transgene Expression by Icodextrin in Animal Models;” Clinical Cancer Research; Nov. 2002; vol. 6; No. 11; p. 516.
Verma, Inder M., et al., “Gene Therapy—Promises, Problems and Prospects;” Nature, Sep. 18, 1997; vol. 389, pp. 239-242.
Palu, Giorgio, et al., “In Pursuit of New Developments for Gene Therapy of Human Diseases;” Biotechnology; 1999; vol. 68, pp. 1-13.
Luo, Dan, et al., “Synthetic DNA Delivery Systems;”Nature Biology; 2000; vol. 18, pp. 33-37.
Fox, Jeffrey L.; “Gene Therapy Clinical Trials Raise Troubling Questions;” ASM News, Feb. 2000; vol. 66, No. 2, pp. 1-3.
Conroy Susan E.
Engler Heidrun
Maneval Daniel C.
Canji Inc.
Innovata Limited
Townsend and Townsend / and Crew LLP
Vogel Nancy
LandOfFree
Nucleic acid delivery does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid delivery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid delivery will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4027682