Nucleic acid delivery

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Reexamination Certificate

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C435S320100

Reexamination Certificate

active

07094583

ABSTRACT:
The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced delivery of nucleic acids, particularly eucaryotic expression vectors, demonstrate enhanced delivery of nucleic acids to cells in vivo. The present invention also provides methods of treatment in combination with such formulations.

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Engler, Heidrun et al., Enhancement of intraperitoneal adenovirus mediated transgene expression by icodextrin in animal models, Nov. 2002, Clinical Cancer Research, vol. 6, No. 11, p. 516.
International Search Report and Notification of Transmittal of International Search Report (PCT/GB 01/04878) (8 sheets).

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