Nucleic acid crosslinking agent and affinity inactivation of nuc

Details Nucleic acid crosslinking agent and affinity inactivation of nuc Nucleic acid crosslinking agent and affinity inactivation of nuc

1977-03-09

1978-10-31

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 260561H, 536 22, 536 29, C07H 1920, C07H 1910, C07H 2102

Patent

active

041236106

ABSTRACT:
The crosslinking agent contains an acylhydrazide moiety, through which it is linked to a cytosine residue on the first chain; and an .alpha.-haloketal moiety which, after attachment of the crosslinking agent to the first chain, is hydrolyzed to an .alpha.-haloketone moiety, through which linking is effected to the base-paired guanine residue on the second chain.

REFERENCES:
patent: 2355911 (1944-08-01), Graenacher et al.
patent: 3133912 (1964-05-01), Kimmig et al.
patent: 4018916 (1977-04-01), VereHodge
patent: 4021542 (1977-05-01), Schmidt et al.

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