Nucleic acid-containing polymerizable complex

Details Nucleic acid-containing polymerizable complex Nucleic acid-containing polymerizable complex

1997-03-05

1999-08-03

Marschel, Ardin H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 253, C07H 1900, C07H 2102, C07H 2100

Patent

active

059327111

ABSTRACT:
Disclosed is a polymerizable complex containing a covalently attached nucleic acid molecule which, under appropriate conditions, is capable of copolymerization with a second polymerizable ethylene-containing monomer unit to form a polymerized layer. The polymerized layer containing attached nucleic acid is useful in a variety of contexts including, for example, hybridization assays. The polymerized layer containing the covalently attached nucleic acid molecule can be formed into a variety of shapes, or attached to a formed material through appropriate chemistry.

REFERENCES:
Lamture et al., Direct detection of nucleic acid hybridization on the surface of a charge soupled device, Nucleic Acids Research 22: 2121 (1994).
Caruther et al., Chemical synthesis of deoxyoligonucleotides by the phosphoramidite method, Methods in Enzymology 156: 230 (1985).
Shumaker et al., Mutation detection by solid phase primer extension, Hum. Mutat. 7: 346 (1996).
Southern, DNA chips: analysing sequence by hybridization to oligonucleotides on a large scale, Trends in Genetics 12: 110(1996).
Sandler and Karo, Polymer Synthesis : Chapters 10 and 12 (1992).
Livache et al., Nucleic Acids Research 22: 2915-2921 (1994).

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