Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2006-05-16
2006-05-16
Woitach, Joseph (Department: 1635)
Chemistry: molecular biology and microbiology
Vector, per se
C435S325000
Reexamination Certificate
active
07045346
ABSTRACT:
Unique multifunctional nucleotide expression cassettes comprising a nucleotide sequence encoding a human protease driven by a glucose-regulatable promoter, a nucleotide sequence encoding human proinsulin having sites at its B-C and C-A junctions altered to permit cleavage by the human protease, and a CMV promoter driving the transcription of the nucleotide sequence encoding the human proinsulin, such cassettes optionally having polyadenylation sequences after each structural gene and the nucleotide sequence encoding human proinsulin optionally carrying an H10D variant, and cells transformed thereby.
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Simon C. Barry et al; Glucose-Regulated Insulin Expression in Diabetic Rats; Human Gene Therapy Jan. 20, 2001 vol. 12 pp. 131-139; Department of Pediatrics and Department of Medicine, Seattle, WA. 98195.
Barton Randall Wilber
Schneiderman Richard
Tatake Revati J.
Boehringer Ingelheim Pharmaceuticals Inc.
Devlin Mary-Ellen M.
Morris Michael P.
Stempel Alan R.
Whiteman Brian
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