Nucleic acid constructs, pharmaceutical compositions and...

Details Nucleic acid constructs, pharmaceutical compositions and... Nucleic acid constructs, pharmaceutical compositions and...

2006-09-21

2011-10-11

Bertoglio, Valarie (Department: 1632)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S024100, C536S024200, C536S023400

Reexamination Certificate

active

08034914

ABSTRACT:
A nucleic acid construct that includes (i) a first nucleic acid sequence encoding TNF alpha; (ii) a second nucleic acid sequence encoding a Diphtheria toxin; and (iii) at least one additional nucleic acid sequence of a cancer specific promoter. The TNF alpha and Diphtheria toxin encoding sequences are under an expression control of the cancer specific promoter. Also provided are construct systems and methods and uses of same.

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